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microsomal protein content of liver  (Simcyp)

 
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    Simcyp microsomal protein content of liver
    Microsomal Protein Content Of Liver, supplied by Simcyp, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/microsomal protein content of liver/product/Simcyp
    Average 90 stars, based on 1 article reviews
    microsomal protein content of liver - by Bioz Stars, 2026-05
    90/100 stars

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    Human hepatic CYP content (pmol/mg microsomal protein) for CYP2C9, CYP2C19, CYP2E1, CYP3A4, CYP3A5 and CYP3A7 plotted against age. For each individual plot, the center of the three lines is the average CYP content while the upper and lower two lines represent the 95% confidence intervals. Equations generated from plots are utilized in the human heapatic CYP content calculator (http://wings.buffalo.edu/smbs/pmy/resources/Cyp%20Calculator.htm).

    Journal: Toxicology

    Article Title: Cytochrome P450-specific human PBPK/PD models for the organophosphorus pesticides: chlorpyrifos and parathion

    doi: 10.1016/j.tox.2011.04.002

    Figure Lengend Snippet: Human hepatic CYP content (pmol/mg microsomal protein) for CYP2C9, CYP2C19, CYP2E1, CYP3A4, CYP3A5 and CYP3A7 plotted against age. For each individual plot, the center of the three lines is the average CYP content while the upper and lower two lines represent the 95% confidence intervals. Equations generated from plots are utilized in the human heapatic CYP content calculator (http://wings.buffalo.edu/smbs/pmy/resources/Cyp%20Calculator.htm).

    Article Snippet: CYP content (pmol P450/mg microsomal protein) was plotted against age (log[days]) using MATLAB (The Mathworks Inc; Natick, MA) to generate curves ( ).

    Techniques: Generated

    A comparison of metabolic parameters for PBPK/PD models published by Timchalk et al. (2002) and the refined human CYP-specific models.

    Journal: Toxicology

    Article Title: Cytochrome P450-specific human PBPK/PD models for the organophosphorus pesticides: chlorpyrifos and parathion

    doi: 10.1016/j.tox.2011.04.002

    Figure Lengend Snippet: A comparison of metabolic parameters for PBPK/PD models published by Timchalk et al. (2002) and the refined human CYP-specific models.

    Article Snippet: CYP content (pmol P450/mg microsomal protein) was plotted against age (log[days]) using MATLAB (The Mathworks Inc; Natick, MA) to generate curves ( ).

    Techniques: Comparison, Activation Assay

    The resulting output for human hepatic CYP content for a 1 year old and 19 year old using the human hepatic CYP content calculator.

    Journal: Toxicology

    Article Title: Cytochrome P450-specific human PBPK/PD models for the organophosphorus pesticides: chlorpyrifos and parathion

    doi: 10.1016/j.tox.2011.04.002

    Figure Lengend Snippet: The resulting output for human hepatic CYP content for a 1 year old and 19 year old using the human hepatic CYP content calculator.

    Article Snippet: CYP content (pmol P450/mg microsomal protein) was plotted against age (log[days]) using MATLAB (The Mathworks Inc; Natick, MA) to generate curves ( ).

    Techniques:

    Human PBPK/PD model simulations of the time course for AChE (solid line) and BuChE (dashed line) inhibition following a single oral exposure to chlorpyrifos or parathion in infants and adults. Average hepatic CYP content for the two ages (Table 2) and protein binding values for chlorpyrifos (Timchalk et al. 2002b) and parathion (Table 3) were utilized.

    Journal: Toxicology

    Article Title: Cytochrome P450-specific human PBPK/PD models for the organophosphorus pesticides: chlorpyrifos and parathion

    doi: 10.1016/j.tox.2011.04.002

    Figure Lengend Snippet: Human PBPK/PD model simulations of the time course for AChE (solid line) and BuChE (dashed line) inhibition following a single oral exposure to chlorpyrifos or parathion in infants and adults. Average hepatic CYP content for the two ages (Table 2) and protein binding values for chlorpyrifos (Timchalk et al. 2002b) and parathion (Table 3) were utilized.

    Article Snippet: CYP content (pmol P450/mg microsomal protein) was plotted against age (log[days]) using MATLAB (The Mathworks Inc; Natick, MA) to generate curves ( ).

    Techniques: Inhibition, Protein Binding

    Effect of varying hepatic CYP content on human PBPK/PD model simulations for a 19yr old following a single oral exposure to chlorpyrifos.

    Journal: Toxicology

    Article Title: Cytochrome P450-specific human PBPK/PD models for the organophosphorus pesticides: chlorpyrifos and parathion

    doi: 10.1016/j.tox.2011.04.002

    Figure Lengend Snippet: Effect of varying hepatic CYP content on human PBPK/PD model simulations for a 19yr old following a single oral exposure to chlorpyrifos.

    Article Snippet: CYP content (pmol P450/mg microsomal protein) was plotted against age (log[days]) using MATLAB (The Mathworks Inc; Natick, MA) to generate curves ( ).

    Techniques: Inhibition

    Effect of varying hepatic CYP content on human PBPK/PD model simulations for a 19yr old following a single oral exposure to parathion.

    Journal: Toxicology

    Article Title: Cytochrome P450-specific human PBPK/PD models for the organophosphorus pesticides: chlorpyrifos and parathion

    doi: 10.1016/j.tox.2011.04.002

    Figure Lengend Snippet: Effect of varying hepatic CYP content on human PBPK/PD model simulations for a 19yr old following a single oral exposure to parathion.

    Article Snippet: CYP content (pmol P450/mg microsomal protein) was plotted against age (log[days]) using MATLAB (The Mathworks Inc; Natick, MA) to generate curves ( ).

    Techniques: Inhibition